Purpose The purpose of this study was to investigate the effect of neuromuscular stimulation on respiratory system and cardiovascular system according to exercise load test time. Methods The experiment was performed in 20 experimental groups and 20 control groups, and a total of 5 neuromuscular stimuli were attached to the rectus femoris, gluteus maximus and abdominal muscles. A total of eight measurements before, during and after exercise were compared between groups. Results There was no significant difference in body weight before / after comparison between groups (p> 0.05), but body fat mass was significantly different between groups (p <0.05). Maximum oxygen uptake, maximum carbon dioxide emissions, and gas exchange rates were significantly different between the two groups at 3, 6, and 9 minutes after the exercise test. There was a significant difference in heart rate and systolic blood pressure between two groups at 3 minutes after exercise. Conclusion In conclusion, neuromuscular electrical stimulation could affect the respiratory system and cardiovascular variables, and it was confirmed that there was a change in body fat loss. In addition, neuromuscular electric stimulation could be applied for portable attachment, so it is possible to help weight reduction as energy expenditure would be increased while exercising.