Purpose The purpose of this study was to confirm the effects of scrambler and stretching application on depression, anxiety, and pain, which are psychogenic changes in breast cancer patients. Methods The subjects of this study were randomly assigned to 24 breast cancer patients, 12 in the scrambler and stretch application group, and 12 in the transcutaneous nerve muscle electrical stimulation and stretching application group. They were applied for 1 hour a day, 5 times a week, for a total of 3 weeks. Within-group changes were analyzed by a paired t-test, and between-group changes were analyzed using an independent t-test, with a significance level of 0.05. Results As a result of this study, depression was significantly reduced in the intra-group change between the experimental group and the control group (p<0.05), and there was also a significant difference in the intra-group change (p<0.05). Anxiety and pain were significantly reduced in the within-group change (p<0.05) and there was no significant difference in the between-group change (p>0.05). Conclusion By disrupting pain signals of C-fibers with electrical stimulation, reducing the intensity of pain so that the brain cannot recognize it as pain, it is presumed to improve depression, anxiety, and distress, thus potentially impacting the enhancement of quality of life.